Nobiletin Prevents Obesity-Related Complications and Neurological Disorders: An Overview of Preclinical and Clinical Studies

Nobiletin (NOB) chemically known as 5, 6, 7, 8, 3, 4-hexamethoxyflavone is a polymethoxylated flavonoid that predominantly found in the peel of citrus fruits. Animal studies and limited number clinical trials suggest NOB has multifunctional biological activities such protection against obesity related cardiometabolic disorders, neuroprotection, antidiabetic, anticancer, anti-allergy, antioxidant, anti-inflammatory, free radical scavenging abilities. its metabolites have also displayed antibacterial antiviral properties inhibition hepatic lipogenesis. This review intended to discuss pharmacological actions therapeutic potential prevention associated health complications. Evidence obtained from animal may be promising candidate for disorders well non-communicable diseases. Further are needed understand mechanism action at cellular, genetic, molecular levels. Keywords: Nobiletin, obesity, lipogenesis, antiatherogenesis.